Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Moderately Good
Based on 20 Reviews
7.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%

Top Medical Research Studies

We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.

In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.

Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
Read More
9.5
Selenium nanoparticles combat bacterial infections
We explored how selenium nanoparticles (SeNPs) can tackle bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). By modifying the surface chemistry of SeNPs using different surfactants, we could influence their effectiveness in fighting bacteria and modulating immune responses.

Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.

In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Read More
We explored the potential of selenium nanoparticles (SeNPs) as a treatment option for Pseudomonas aeruginosa, a notorious bacteria known for its antibiotic resistance and ability to form biofilms. The study examined how effectively these SeNPs can target bacterial infections, particularly focusing on their antibacterial and anti-biofilm properties.

SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.

Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.

Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
Read More

Most Useful Reviews

9
Enhances immune system
Selenium is crucial for immune function. Insufficient levels can increase infection rates. This supplement has been shown to enhance the performance of white blood cells, helping to combat both infections and cancers.
Read More
9
Reduces oxidative stress
I've taken selenium for years in cycles. It boosts immune defence and curtails cell damage due to free radicals. This essential mineral also links to mitigating viral infections and thyroid function, crucial for preventing illness linked to selenium deficiency.
Read More
8
Quick recovery
3 people found this helpful
I bought this during a cold, and I feel I recovered quickly. The grains are slightly larger but not drinkable.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
  • All Researches
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.

In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.

Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
Read More
9.5
Selenium nanoparticles combat bacterial infections
We explored how selenium nanoparticles (SeNPs) can tackle bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). By modifying the surface chemistry of SeNPs using different surfactants, we could influence their effectiveness in fighting bacteria and modulating immune responses.

Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.

In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Read More
9.5
We delved into how selenium nanoparticles (SeNPs) can raise our body's defenses against bacterial infections, specifically Mycobacterium bovis, which causes tuberculosis. The study focused on combining SeNPs with an antigen called AH (Ag85A-HspX) to see if this partnership could improve respiratory mucosal immunity and enhance protection against this serious illness.

In our exploration, we synthesized SeNPs and administered them intranasally in mice, alongside the AH antigen. The results were quite enlightening. SeNPs proved to be more effective than polyinosinic-polycytidylic acid (Poly IC) in stimulating dendritic cells, which play a crucial role in activating our immune response. This activation led to a significant increase in tissue-resident memory T cells and effector CD4 T cells in the lungs, strengthening the overall immune response to the infection.

Moreover, mice that received the combination of AH and SeNPs demonstrated impressive outcomes. There was a notable increase in specific antibody levels in the respiratory system, along with a boost in immune markers associated with fighting infections. Not only did these mice show enhanced mucosal immunity, but they also had lower infection loads and reduced inflammatory damage in their lungs after being challenged with M. bovis. Overall, this study highlights the potential of selenium nanoparticles as innovative adjuvants in vaccines, paving the way for future clinical investigations in both cattle and possibly humans.
Read More
9.5
Nano-based treatment for infections
We explored how selenium-tellurium doped copper oxide nanoparticles (SeTe-CuO NPs) can effectively tackle bacterial infections and improve wound healing. This innovative study focused on the nanoparticles’ dual photodynamic and photothermal properties, which become activated under near-infrared (NIR) light.

In our findings, these nanoparticles demonstrated a remarkable ability to eradicate up to 99% of bacteria and showed significant inhibition of biofilm formation. This is crucial, as biofilms can make infections harder to treat. The in vitro tests established that these NPs effectively combat bacterial infections, leading us to believe they have practical applications for improving wound recovery.

We also observed that, when implemented in vivo, the SeTe-CuO NPs significantly accelerated the closure of wounds. They helped clear bacteria quickly from wounds, offering a promising solution for those struggling with infections. Overall, the study highlights a powerful new tool in the fight against multidrug-resistant bacteria, demonstrating its potential in advancing therapeutic interventions in wound management.
Read More
9
Hybrid nanoparticles show antibacterial promise
We explored how combining selenium-tellurium nanoparticles with zinc oxide can help tackle bacterial infections, especially those stubborn biofilms. The goal was to create a hybrid nanoparticle that could leverage both photodynamic and photothermal properties to effectively disrupt bacterial growth.

In our synthesis of these SeTe-ZnO nanoparticles, we observed a significant impact on both Gram-positive and Gram-negative bacteria. Not only did these nanoparticles show efficacy in combating various bacterial strains, they also played a role in disrupting biofilm formation, which is often a major barrier to treatment success.

Furthermore, studies indicated that the SeTe-ZnO nanoparticles are biocompatible, which means they are safe to use in biological contexts, such as wound healing. Their impressive wound healing abilities suggest they could be a versatile option in both preventing and treating infections, demonstrating promising potential in the field of antimicrobial therapy.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 20 Reviews
7.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Enhances immune system
Selenium is crucial for immune function. Insufficient levels can increase infection rates. This supplement has been shown to enhance the performance of white blood cells, helping to combat both infections and cancers.
Read More
9
Reduces oxidative stress
I've taken selenium for years in cycles. It boosts immune defence and curtails cell damage due to free radicals. This essential mineral also links to mitigating viral infections and thyroid function, crucial for preventing illness linked to selenium deficiency.
Read More
8
Quick recovery
3 people found this helpful
I bought this during a cold, and I feel I recovered quickly. The grains are slightly larger but not drinkable.
Read More
8
Strong immunity support
2 people found this helpful
This good product serves a prophylactic purpose. I take 200 mg for hypothyroidism; healthy immunity is essential for combating bacteria and viruses. Selenium supports the immune response by providing protection against free radicals and reducing cell damage, ultimately lowering disease risk. Additionally, selenium has shown anti-inflammatory and antibacterial properties.
Read More
7.5
Preventive measure
Selenium is recognised for preventing coronavirus infections. I switched from Solgar to this more affordable option, which contains fewer impurities and provides good daily dosage.
Read More

Frequently Asked Questions

7.5
Fights infection effectively
An essential supplement for health, selenium strengthens the body’s ability to combat infections. I’ve been taking one daily for two months, and my body has reacted positively. My brother-in-law, who has thyroid issues, has also experienced improvements.
8
Quick recovery
3 people found this helpful
I bought this during a cold, and I feel I recovered quickly. The grains are slightly larger but not drinkable.
8
Strong immunity support
2 people found this helpful
This good product serves a prophylactic purpose. I take 200 mg for hypothyroidism; healthy immunity is essential for combating bacteria and viruses. Selenium supports the immune response by providing protection against free radicals and reducing cell damage, ultimately lowering disease risk. Additionally, selenium has shown anti-inflammatory and antibacterial properties.
6
Reduces inflammation risk
Vitamin C supports immunity, while selenium is equally critical. It effectively prevents both viral and bacterial infections and mitigates inflammation, especially vital in winter.
9
Enhances immune system
Selenium is crucial for immune function. Insufficient levels can increase infection rates. This supplement has been shown to enhance the performance of white blood cells, helping to combat both infections and cancers.
6
Improved well-being
16 people found this helpful
Creates a relaxed state of well-being. I had symptoms indicating thyroid issues and started taking selenium with iodine. I felt a remarkable sense of well-being and relaxation almost immediately upon taking the iodine supplement. It has significantly alleviated my hypothyroid symptoms. Though iodine is beneficial, do research on Hashimoto's thyroiditis as it isn't always recommended. I've also switched to a stronger iodine supplement alternative, which seems to have caused a cyst to burst. Thankfully, this brought relief from some pain but led to concerns about bacterial infection. To prevent this, I increased my iodine intake and have felt fine since. This crucial vitamin is essential, particularly if you do not consume fish. Since adding selenium to my routine, my well-being has further improved.
6
Supports immune health
A very necessary vitamin for immunity. It protects against infections. I also take zinc.
7.5
Facilitates recovery period
A good quality product; I use it for my thyroid on my nutritionist's advice. They helped me recover quickly and easily during a coronavirus infection, with no lasting consequences.
6
Promotes healing benefits
Selenium 100 mcg, 250 tablets, is a powerful antioxidant. It prevents cellular damage and the onset of diseases caused by viruses and bacterial infections. A proven manufacturer I trust. The order arrived promptly.
7.5
Protects cell health
I've taken selenium for a long time due to its benefits for hormonal balance and heart health. Low selenium levels can lead to serious health issues, including bacterial infections. It's crucial to monitor selenium, especially in winter.
7
Selenium may protect against infection
We aimed to understand how exposure to selenium, a trace element, affects the risk of Streptococcus infection in children. Our study utilized data gathered from over 100,000 pregnancies across Japan, providing a comprehensive look at maternal health and child outcomes.

We specifically focused on measuring levels of toxic metals and trace elements in pregnant mothers and assessing the incidence of Streptococcus infections in their children around the age of three to four. Through our analysis, we found that higher levels of selenium were associated with a reduced risk of Streptococcus infections.

Interestingly, while both selenium and mercury appeared to have protective associations with infection rates, our examination did not find any significant interaction between these two elements. These findings suggest that maternal selenium exposure could play a beneficial role in safeguarding children from this common bacterial infection.
9
Hybrid nanoparticles show antibacterial promise
We explored how combining selenium-tellurium nanoparticles with zinc oxide can help tackle bacterial infections, especially those stubborn biofilms. The goal was to create a hybrid nanoparticle that could leverage both photodynamic and photothermal properties to effectively disrupt bacterial growth.

In our synthesis of these SeTe-ZnO nanoparticles, we observed a significant impact on both Gram-positive and Gram-negative bacteria. Not only did these nanoparticles show efficacy in combating various bacterial strains, they also played a role in disrupting biofilm formation, which is often a major barrier to treatment success.

Furthermore, studies indicated that the SeTe-ZnO nanoparticles are biocompatible, which means they are safe to use in biological contexts, such as wound healing. Their impressive wound healing abilities suggest they could be a versatile option in both preventing and treating infections, demonstrating promising potential in the field of antimicrobial therapy.
We explored the potential of selenium nanoparticles (SeNPs) as a treatment option for Pseudomonas aeruginosa, a notorious bacteria known for its antibiotic resistance and ability to form biofilms. The study examined how effectively these SeNPs can target bacterial infections, particularly focusing on their antibacterial and anti-biofilm properties.

SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.

Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.

Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.

In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.

Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.

References

  1. Iwata H, Ikeda A, Itoh M, Ketema RM, Tamura N, et al. Association between prenatal exposure to maternal metal and trace elements and Streptococcus infection: A prospective birth cohort in the Japan Environment and Children's Study. PLoS One. 2025;20:e0319356. doi:10.1371/journal.pone.0319356
  2. Wang Y, Khan SS, Ullah I, Rady A, Aldahmash B, et al. One pot synthesis of SeTe-ZnO nanoparticles for antibacterial and wound healing applications. RSC Adv. 2025;15:3439. doi:10.1039/d4ra06594h
  3. Perfileva AI, Zakharova OV, Graskova IA, Krutovsky KV. Effect of Selenium, Copper and Manganese Nanocomposites in Arabinogalactan Matrix on Potato Colonization by Phytopathogens and . Plants (Basel). 2024;13. doi:10.3390/plants13243496
  4. Dong J, Wang Z, Fei F, Jiang Y, Jiang Y, et al. Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways. Vet Sci. 2024;11. doi:10.3390/vetsci11120674
  5. Thamayandhi C, El-Tayeb MA, Syed SR, Sivaramakrishnan R, Gunasekar B. Antibacterial and anti-biofilm efficacy of selenium nanoparticles against Pseudomonas aeruginosa: Characterization and in vitro analysis. Microb Pathog. 2024;196:106998. doi:10.1016/j.micpath.2024.106998
  6. Tran P, Abidi N, Bergfeld N, Shashtri M, Reid TW. Selenium Bandages and Cotton Cloth That Kill Microorganisms in Wounds. Mil Med. 2024;189:179. doi:10.1093/milmed/usae069
  7. Wang Y, Feng L, Jiang WD, Wu P, Liu Y, et al. The effect of selenium on the intestinal health of juvenile grass carp based on the ERS-autophagy pathway. Fish Shellfish Immunol. 2024;153:109808. doi:10.1016/j.fsi.2024.109808
  8. Canbaz FA, Yurtçu M, Oltulu P, Taştekin G, Kocabaş R, et al. Investigation of the Effects of N-acetylcysteine and Selenium on Vesicoureteral Reflux Nephropathy: An Experimental Study. J Pediatr Surg. 2024;59:161616. doi:10.1016/j.jpedsurg.2024.06.024
  9. Gamal AA, Hussein MAM, Sayed HAE, El-Sayed EM, Youssef AM, et al. Hybrid nanoparticles combining nanoselenium-mediated Carica papaya extract and trimethyl chitosan for combating clinical multidrug-resistant bacteria. Int J Biol Macromol. 2024;277:134359. doi:10.1016/j.ijbiomac.2024.134359
  10. Joshi P, Soares JM, Martins GM, Zucolotto Cocca LH, De Boni L, et al. Enhancing the efficacy of antimicrobial photodynamic therapy through curcumin modifications. Photochem Photobiol. 2025;101:359. doi:10.1111/php.14000
  11. Gokhale KM, Patravale V, Pingale R, Pandey P, Vavilala SL. Se-functionalized ZIF-8 nanoparticles: synthesis, characterization and disruption of biofilms and quorum sensing in. Biomed Mater. 2024;19. doi:10.1088/1748-605X/ad6549
  12. Bian Y, Zhao K, Hu T, Tan C, Liang R, et al. A Se Nanoparticle/MgFe-LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction. Adv Sci (Weinh). 2024;11:e2403791. doi:10.1002/advs.202403791
  13. Bu Q, Jiang D, Yu Y, Deng Y, Chen T, et al. Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection. Drug Resist Updat. 2024;76:101102. doi:10.1016/j.drup.2024.101102
  14. Ge X, Liang Z, Li K, Dong Y, Wang Y, et al. Selenium nanoparticles enhance mucosal immunity against Mycobacterium bovis infection. Int Immunopharmacol. 2024;137:112384. doi:10.1016/j.intimp.2024.112384
  15. Yang F, Shu R, Dai W, Li B, Liu C, et al. HSe-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence. Biomaterials. 2024;311:122659. doi:10.1016/j.biomaterials.2024.122659
  16. Ullah I, Khan SS, Ahmad W, Liu L, Rady A, et al. NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing. Commun Chem. 2024;7:131. doi:10.1038/s42004-024-01215-1
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